Nucleic Acids Chemistry and Engineering: Special Issue on Nucleic Acid Conjugates for Biotechnological Applications

Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.

Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides f...

Nucleic acid chemistry

Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick [1], we know that DNA is of critical importance, carrying the genetic information for all living organisms. Only a few years later appeared the first reports on the chemical synthesis of oligonucleotides with a natural 3'-5' phosphodiester linker by Michelsen and Todd [2]. It took another two decades until ...

Physical chemistry of nucleic acids.

The Watson-Crick double helix of DNA was first revealed in 1953. Since then a wide range of physical chemical methods have been applied to DNA and to its more versatile relative RNA to determine their structures and functions. My major goal is to predict the folded structure of any RNA from its sequence. We have used bulk and single-molecule measurements of thermodynamics and kinetics, plus var...

Early nucleic acid chemistry.

,g i:. The contemporary biochemist, perusing the publications of the past century, may easily be misled into some arrogance when sorting out the erroneous data and leads, the slow progress and the primitive reports of that early period. However, when recalling the limited techniques and the lack of facilities at the early stages of biochemistry, he will change his mind. The difficulties encount...

Twentyfourth Symposium on Nucleic Acids Chemistry Held